---
title: Integrating Raman Spectroscopy and Genome-Scale Modeling to Enhance AAV Upstream Manufacturing
description: Learn how Viralgen is combining Raman spectroscopy and genome-scale modeling to improve AAV upstream manufacturing, enabling smarter, faster, and more reliable gene therapy production.
---

[Resources | Viralgen ](https://viralgen.com/resources)

# [Integrating Raman Spectroscopy and Genome-Scale Modeling to Enhance AAV Upstream Manufacturing](https://viralgen.com/resources/integrating-raman-spectroscopy-and-genome-scale-modeling-to-enhance-aav-upstream-manufacturing)

 Written by [Itsasne Arangoa](https://viralgen.com/resources/author/itsasne-arangoa) | May 13, 2025 4:00:00 AM

As gene therapies continue to revolutionize medicine, manufacturers are under pressure to produce adeno-associated virus (AAV) vectors more efficiently and at higher quality. Viralgen is tackling this challenge head-on by integrating **Raman spectroscopy** with **genome-scale metabolic modeling** to optimize AAV upstream manufacturing.

In our latest research collaboration with Universidad de Navarra, Viralgen demonstrates how real-time monitoring of critical parameters can significantly improve process understanding and control.

### Key Innovations:

- **Raman spectroscopy** enables real-time, non-invasive tracking of key metabolites during AAV production.
- **Genome-scale metabolic modeling (GEMs)** predicts cellular behavior and optimizes nutrient feeding strategies.
- The approach enhances upstream process consistency and supports better control of product yield and quality.

[View full post](https://viralgen.com/resources/integrating-raman-spectroscopy-and-genome-scale-modeling-to-enhance-aav-upstream-manufacturing)

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