Integrating Raman Spectroscopy and Genome-Scale Modeling to Enhance AAV Upstream Manufacturing

As gene therapies continue to revolutionize medicine, manufacturers are under pressure to produce adeno-associated virus (AAV) vectors more efficiently and at higher quality. Viralgen is tackling this challenge head-on by integrating Raman spectroscopy with genome-scale metabolic modeling to optimize AAV upstream manufacturing.

In our latest research collaboration with Universidad de Navarra, Viralgen demonstrates how real-time monitoring of critical parameters can significantly improve process understanding and control.

Key Innovations:

• Raman spectroscopy enables real-time, non-invasive tracking of key metabolites during AAV production.
• Genome-scale metabolic modeling (GEMs) predicts cellular behavior and optimizes nutrient feeding strategies.
• The approach enhances upstream process consistency and supports better control of product yield and quality.